A recent security update to the MySQL Ubuntu deb packages can break authentication with connecting clients. This can potentially have a significant impact on Charmed OpenStack deployments. A fix is underway.
After upgrading and restarting both mysql-router (does not happen automatically) and mysql server (does happen automatically) to the new 8.0.32 version clients using the pymysql library and connecting via mysql-router will fail to connect.
See bug LP# 2003835 for details.